Largazole: From discovery to broad-spectrum therapy
نویسندگان
چکیده
منابع مشابه
Largazole: from discovery to broad-spectrum therapy.
The cyclic depsipeptide largazole from a cyanobacterium of the genus Symploca is a marine natural product with a novel chemical scaffold and potently inhibits class I histone deacetylases (HDACs). Largazole possesses highly differential growth-inhibitory activity, preferentially targeting transformed over non-transformed cells. The intriguing structure and biological activity of largazole have ...
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ژورنال
عنوان ژورنال: Natural Product Reports
سال: 2012
ISSN: 0265-0568,1460-4752
DOI: 10.1039/c2np00066k